文献类型：期刊文献

英文题名：Copper-Catalyzed Remote Asymmetric Three-Component Sulfonylation Using SO2 as the Sulfur Source to Access Chiral Allylic Sulfones

作者：Li, Jiale[1];Yan, Wenli[1];Liu, Shuning[2];Guo, Jiaxing[1];Ma, Xiang[3,4];Xiang, Huijing[2];Li, Xingguang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China;[3]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Inst Fine Chem,Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2026

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001770281600001)】；

基金：We thank the financial aid from the National Natural Science Foundation of China (Nos. 22571083, T2522014, 22201073, T2322018, 32171391, and 22471191), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM404), and the Fundamental Research Funds for the Central Universities. We thank the Research Center of Analysis and Test of East China University of Science and Technology for help in the characterization.

语种：英文

摘要：A copper-catalyzed enantioselective sulfonylation of yne-allylic esters with sulfur dioxide and cyclopropan-1-ols is reported. This three-component reaction proceeds via selective epsilon-addition of gamma-keto sulfinate to copper-allenylidene intermediates, enabling efficient synthesis of chiral allylic sulfones under mild conditions. The protocol features high enantioselectivity (up to 96% ee), broad functional group compatibility, and good yields.