文献类型：期刊文献

中文题名：聚合物纳米微球制备实验设计

英文题名：Design of teaching experiment for preparation of polymeric nanospheres

作者：徐菊美[1];岑莲[1];胡江林[1];张昊舟[1]

机构：[1]华东理工大学化学工程系,上海200237

年份：2016

卷号：33

期号：3

起止页码：58

中文期刊名：实验技术与管理

外文期刊名：Experimental Technology and Management

收录：CSTPCD;;北大核心:【北大核心2014】；

基金：上海市高校实验技术队伍建设计划项目(2013);华东理工大学本科教育教学改革项目(2013014)

语种：中文

中文关键词：聚合物纳米粒;乳化-溶剂挥发法;微流;教学实验设计;能力培养

外文关键词：polymeric nanoparticles; emulsion-solvent evaporation; microfluidics; design of teaching experiment; ability training

摘要：介绍并比较了乳化-溶剂挥发法和微流控技术制备聚合物载药纳米粒的工艺特点,以形貌和粒度为评价指标,在一定优化工艺条件下制备得到光滑圆整、平均粒径为200nm的SB-3CT-PLGA纳米粒。该研究项目用于教学实验,有利于学生综合能力的培养,比如:掌握不同实验技术解决问题的能力,设计并组织实验、分析数据的能力及团队协作能力。
The emulsion-solvent evaporation and microfluidics techniques are applied in the current work to prepare SB-3CT loaded poly（1actic-co-glycolic acid）nanoparticles.The advantages and disadvantages of both methods are compared.It was shown that spherical SB-3CT-PLGA nanoparticles with a smooth surface and narrow distribution of a mean diameter of 200 nm could be obtained at an optimal condition.This research project could be further adopted to experimental teaching to promote comprehensive ability training of undergraduates,such as acquisition of alternative experimental techniques or skills to solve engineering problems,ability to conduct experiments and interpret data,and team-work cooperation ability.