文献类型：期刊文献

英文题名：A Short and Practical Synthesis of Oseltamivir Phosphate (Tamiflu) from (-)-Shikimic Acid

作者：Nie, Liang-Deng[1];Shi, Xiao-Xin[1];Ko, Kwang Hyok[1];Lu, Wei-Dong[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Engn, Shanghai 200237, Peoples R China

年份：2009

卷号：74

期号：10

起止页码：3970

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20092312106210);WOS:【SCI-EXPANDED(收录号:WOS:000265991200055)，CCR-EXPANDED(收录号:WOS:000265991200055)】；

基金：We are grateful to the Chinese National Science Foundation (No. A-20172015) and the Shanghai Educational Development Foundation (The Dawn Program: No. 03SG27) for financial support of this work. K.H.K. would like to thank Ham Huang University of Pharmacy, Democratic People's Republic of Korea.

语种：英文

摘要：Oseltamivir phosphate (1) was synthesized from (-)-shikimic acid through a short and practical synthetic route via eight steps in 47% overall yield. In addition, the highly regioselective and stereoselective nucleophilic replacement of OMs by the N-3 group in the third and seventh steps has been studied in detail, and the reaction conditions were optimized.