文献类型：期刊文献

英文题名：Synthesis and chiral purification of 14C-labeled novel neonicotinoids, paichongding

作者：Li, Chao[1];Xu, Xiao-Yong[1];Li, Ju-Ying[2];Ye, Qing-Fu[2];Li, Zhong[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Zhejiang Univ, Inst Nucl Agr Sci, Hangzhou 310029, Zhejiang, Peoples R China

年份：2011

卷号：54

期号：13

起止页码：775

外文期刊名：JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

收录：;EI(收录号：20233214506287);WOS:【SCI-EXPANDED(收录号:WOS:000298019000001)】；

基金：This work was supported by a grant from the National Basic Research Program of China (973 Program, 2010CB126104), National High Technology Research, the Development Program of China (863 Program, 2011AA10A207), the National Key Technology R&D Program of China (2011BAE06B01), and Special Fund for Agro-scientific Research in the Public Interest (201103007). This work was also partly supported by the Shanghai Foundation of Science and Technology (09391911800, 09XD1401300), the Shanghai Leading Academic Discipline Project (project no.: B507), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：paichongding; neonicotinoids; radiosynthesis; [14C]nitromethane

摘要：Paichongding, a novel neonicotinoids pesticide with excellent insecticidal activity against imidacloprid-resistant brown planthopper, has been sold in the Chinese market as new pesticide. [14C]Paichongding was proposed as a tracer to support the further study to elucidate the metabolism of the commercialized pesticide. This paper describes an efficient synthesis of [14C]paichongding in five radiochemical steps from [14C]nitromethane (1). Then the four diastereoisomers (a, b, c, and d) were separated by preparative chiral HPLC and characterized by HPLC and HPLC-LSC. This methodology could be utilized in the syntheses of other 14C-labeled nitromethylene neonicotinoids derivatives. Copyright (C) 2011 John Wiley & Sons, Ltd.