文献类型：期刊文献

英文题名：Untying Surface Chemistry and Emulsion Stability to Construct Multifunctional Pickering Emulsion SERS Sensors for Pretreatment-Free Quantitative Analysis in Bio-Media

作者：Zhang, Yingrui[3];Li, Chunchun[1,3];Carland, Ruairi[3];Ye, Ziwei[2];Bell, Steven E. J.[3];Xu, Yikai[2]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Key Lab Adv Mat & Feringa Nobel Prize Scientist Jo, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Queens Univ Belfast, Sch Chem & Chem Engn, Univ Rd, Belfast BT7 1NN, North Ireland

年份：2025

卷号：12

期号：28

外文期刊名：ADVANCED SCIENCE

收录：;EI(收录号：20252018437560);WOS:【SCI-EXPANDED(收录号:WOS:001486931500001)】；

基金：The authors would like to thank Prof He Tian, Prof Xin Xu and Prof Xiang Ma for discussions and support. Young Scientists Fund of the National Natural Science Foundation of China 22402060 (YX). Science and Technology Commission of Shanghai Municipality (grant No.24DX1400200) (YX). Natural Science Foundation of Shanghai (24ZR1416700) (YX). Shanghai Pujiang Program 23PJ1409000 (CL). Shanghai Pujiang Program 23PJ1401900 (ZY). Department of the Economy (N.I.), US-Ireland R&D Partnership Grant USI157 (SB, YZ, CL). Chinese Scholarship Council 202008370188 (YZ)

语种：英文

外文关键词：core-shell; interface self-assembly; internal standard; Pickering emulsion; SERS

摘要：Plasmonic Pickering emulsions have immense potential as enhancing substrates in surface-enhanced Raman spectroscopy (SERS). Traditionally, the functional nanoparticles also act as the emulsion stabilizer, so that their surface chemistry is tied directly to emulsion stability. However, this has meant that adsorption of molecules to the plasmonic nanoparticles destabilizes the emulsion system, which severely limits the use of Pickering emulsions in SERS. Here, we used a dual-particle approach to create plasmonic Pickering emulsions, in which emulsion stability is maintained solely by one type of nanoparticle so that the other could be used to provide functionality without constraints to its surface properties. This allowed us to construct multiwalled carbon nanotubes-Au@Prussian blue Pickering emulsion SERS sensors with integrated internal standards and filtration functionalities, which enabled quantitative, biphasic and multiplex analysis of discrete molecules in serum. The synthetic approach used in this work can be readily extended to form Pickering emulsions carrying functional components with arbitrary surface functionalities, which paves the way for advanced applications in sustainability and healthcare.