文献类型：期刊文献

英文题名：Effects of Rigid Conjugated Groups: Toward Improving Enantioseparation Performances of Chiral Porous Organic Polymers

作者：Tan, Huiling[1,2];Chen, Qibin[1,2];Chen, Tingting[1,2];Liu, Honglai[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2019

卷号：11

期号：40

起止页码：37156

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20194107512061);WOS:【SCI-EXPANDED(收录号:WOS:000490357900094)】；

基金：This work is supported by the National Natural Science Foundation of China, the Fundamental Research Funds for the Central Universities of China and the Ministry of Education of the People's Republic of China. QC. received funding from the National Natural Science Foundation of China (no. 21576079). H.L. received funding from the National Natural Science Foundation of China (no. 91834301) and the Ministry of Education of the People's Republic of China (no. B08021).

语种：英文

外文关键词：porous organic polymers; enantioseparation; conjugated groups; chiral stationary phases; chirality

摘要：The construction of chiral porous materials for practical enantioseparation remains a great challenge. As chiral compounds might display a distinctive spatial orientation in diastereoisomeric complexes between enantiomers and selectors, we reasoned that the conjugated host framework might assist in chiral recognition and thus enhance enantioseparation performances. In this regard, as porous organic polymers (POPs) with chiral selectors are considered as ideal adsorbents, a new kind of POP, COP-1, was thus constructed via introducing an amino acid, as a chiral selector, into rigid and conjugated building blocks, in this work. Results show that the enantiomeric model molecule and drugs are completely separated by gas or column chromatography with COP-1 as chiral stationary phases. Both theoretical and experimental analyses demonstrate that the introduction of conjugated groups generates different host-guest interactions indeed and thus promotes the chiral separation performance. Our findings open up a new possibility for the practical application of enantioseparation at preparative scales.