文献类型：期刊文献

英文题名：Dual-channel signals for intracellular mRNA detection via a PRET nanosensor

作者：Xie, Tao;Li, Meng;Long, Yi-Tao[1]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2017

卷号：53

期号：55

起止页码：7768

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000411278200016)】；

基金：This research was supported by the National Natural Science Foundation of China (21421004, 21327807), the Programme of Introducing Talents of Discipline to Universities (B16017), the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (YJ0130504), the Program of Shanghai Subject Chief Scientist (15XD1501200), and the Fundamental Research Funds for the Central Universities (222201718001, 222201717003).

语种：英文

摘要：An intracellular nanosensor was designed and developed to accurately sense mRNA in living cells without false positive results. This nanosensor consists of gold nanoparticles assembled with recognition sequences and dye-labelled nanoflares. By analyzing both the wavelength shifts and intensity recovery of the scattering spectra, this dual-channel nanosensor could efficiently distinguish and avoid the interference induced by other common substances. This novel dual-channel nanosensor would precisely recognize the target mRNA, and it is promising for further cancer diagnoses.