文献类型：期刊文献

英文题名：Minimal uranium accumulation in lymphoid tissues following an oral 60-day uranyl acetate exposure in male and female C57BL/6J mice

作者：Bolt, Alicia M.[1];Medina, Sebastian[1];Lauer, Fredine T.[1];Xu, Huan[2];Ali, Abdul-Mehdi[3];Liu, Ke Jian[1];Burchiel, Scott W.[1]

机构：[1]Univ New Mexico, Coll Pharm, Dept Pharmaceut Sci, Albuquerque, NM 87131 USA;[2]East China Univ Sci & Technol, Dept Pharmaceut Sci, Sch Pharm, Shanghai, Peoples R China;[3]Univ New Mexico, Dept Earth & Planetary Sci, Albuquerque, NM 87131 USA

年份：2018

卷号：13

期号：10

外文期刊名：PLOS ONE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000448434000043)】；

基金：This work was funded through the NIEHS-EPA UNM Metals Superfund Program #1P42ES025589-01A1 (https://www.niehs.nih.gov/research/supported/centers/srp/index.cfm) to K.J.L. and S.W.B. and UNM Clinical and Translational Science Center Grant UL1TR001449 to S.W.B. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.This work was funded through the NIEHS-EPA UNM Metals Superfund Program 1P42ES025589-01A1 and the UNM Clinical and Translational Science Center Grant UL1TR001449.

语种：英文

摘要：High levels of uranium (U) exist in soil, water, and air in the Southwestern United States due, in part, to waste generated from more than 160,000 abandoned hard rock mines located in this region. As a result, many people living in this region are chronically exposed to U at levels that have been linked to detrimental health outcomes. In an effort to establish a relevant in vivo mouse model for future U immunotoxicity studies, we evaluated the tissue distribution of U in immune organs; blood, bone marrow, spleen, and thymus, as well as femur bones, kidneys, and liver, following a 60-d drinking water exposure to uranyl acetate (UA) in male and female C57BLJ6J mice. Following the 60-d exposure, there was low overall tissue retention of U (<0.01%) at both the 5 and the 50 ppm (mg/L) oral concentrations. In both male and female mice, there was limited U accumulation in immune organs. U only accumulated at low concentrations in the blood and bone marrow of male mice (0.6 and 16.8 ng/g, respectively). Consistent with previous reports, the predominant sites of U accumulation were the femur bones (350.1 and 399.0 ng/g, respectively) and kidneys (134.0 and 361.3 ng/g, respectively) of male and female mice. Findings from this study provide critical insights into the distribution and retention of U in lymphoid tissues following chronic drinking water exposure to U. This information will serve as a foundation for immunotoxicological assessments of U, alone and in combination with other metals.