文献类型：期刊文献

英文题名：Cyclometalated Iridium(III)-Complex-Based Micelles for Glutathione-Responsive Targeted Chemotherapy and Photodynamic Therapy

作者：Xiang, Huijing[1,2];Chen, Hongzhong[2];Tham, Huijun Phoebe[2];Phua, Soo Zeng Fiona[2];Liu, Jin-Gang[1];Zhao, Yanli[2,3]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, 21 Nanyang Link, Singapore 637371, Singapore;[3]Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore

年份：2017

卷号：9

期号：33

起止页码：27553

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20173504088720);WOS:【SCI-EXPANDED(收录号:WOS:000408518800025)】；

基金：We are grateful for the financial support from the National Nature Science Foundation of China (21571062 and 21628401), the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, the Fundamental Research Funds for the Central Universities (No. 222201717003), and the SingHealth-NTU Research Collaborative Grant (No. SHS-NTU/009/2016). H.X. acknowledges the scholarship support from the Chinese Scholarship Council (No. 201506740024).

语种：英文

外文关键词：combinational therapy; cyclometalated Ir(III) complex; glutathione activation; micelles; targeted imaging

摘要：The integration of chemotherapy and photo dynamic therapy (PDT) in a single,delivery system is highly desirable for enhancing anticancer therapeutic efficacy. Herein, two cyclometalated It(III), complex-constructed -micelles Fir-1 and FIr-2 were demonstrated for glutathione (GSH) activated targeted chemotherapy and PDT:The cyclometalated complexes were prepared by conjugating 'phosphorescent Ir(III) compounds With chernOtheiapeutic drug camptothecin (CPT)' through GSH responsive disulfide bond linkages, and the It(III).complexes were then assembled with amphiphilic Surfactant pluronic F127-via noncovalent encapsulation to afford micelles. The surfaces of the micelles were further decorated with folic acid as a targeting 'group. The micelles showed intense fluorescence that renders them with excellent realtime imaging capability. The release of free anticancer drug CPT from the micelles was realized' through GSH-activated disulfide bond cleavage in tumor cells. In addition, the micelles were capable of generating singlet oxygen used for PDT upon visible light irradiation. On account of having folic acid targeting ligand, the micelles-displayed greater cellular accumulation in folate receptor (FR) overexpressed HeLa cells than FR low-expressed MCF-7 cells, leading to selective Cancer cell killing effect. A, compared with solo therapeutic.systems, the micelles with targeted combinational chemotherapy and PDT presented superior potency, andefficacy in killing tumor cells at a low dosage. On the basis of these findings, the multifunctional micelles could serve as a versatile theranostic nanoplatform for cancer cell targeted imaging and combinational therapy.