文献类型：期刊文献

英文题名：A hierarchical nanostructural coating of amorphous silicon nitride on polyetheretherketone with antibacterial activity and promoting responses of rBMSCs for orthopedic applications

作者：Xu, Zhiyan[1];Wu, Han[1];Wang, Fan[1];Kaewmanee, Rames[1];Pan, Yongkang[1];Wang, Deqiang[1];Qu, Pengyu[1];Wang, Zhikang[1];Hu, Gangfeng[2];Zhao, Jun[3];Zhao, Ruiyang[4];Wei, Jie[1]

机构：[1]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]First Peoples Hosp Xiaoshan Dist, 199 Shixinnan Rd, Hangzhou 311200, Zhejiang, Peoples R China;[3]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthodont, Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China;[4]Shihezi Univ, Coll Med, 107 Second North Rd, Shihezi 832002, Xinjiang, Peoples R China

年份：2019

卷号：7

期号：39

起止页码：6035

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20194207552476);WOS:【SCI-EXPANDED(收录号:WOS:000489605400011)】；

基金：The grants were from the National Natural Science Foundation of China (81771990, 81572194), National Key R&D Program (2016YFC1102100) of China, Key Medical Program of Science and Technology Development of Shanghai (19441906100, 17441900600 and 17441902000) of China, and Medical and Health Science and Technology Project in Zhejiang Province (2019KY150) of China.

语种：英文

外文关键词：Alkalinity - Amorphous silicon - Coatings - Plasma enhanced chemical vapor deposition - Body fluids - Inductively coupled plasma - Mammals - Nanostructures - Plasma CVD

摘要：Silicon nitride (SN) with good osteoconductivity has been introduced as an implantable biomaterial for joint replacement and interbody fusion devices. In this study, SN was coated on a polyetheretherketone (PEEK) surface by inductively coupled plasma-enhanced chemical vapor deposition (ICPECVD). The results showed that a dense coating (thickness of about 500 nm) of amorphous SN was closely combined with a PEEK substrate (PKSN) with a binding strength of 6.88 N. In addition, the coating surface showed hierarchical nanostructures containing many spherical bulges (sizes about 150 nm), which were composed of many small humps (sizes about 10 nm). Moreover, the roughness, hydrophilicity, surface energy, surface charge and adsorption of bovine serum albumin (BSA) of PKSN were obviously higher than those of PEEK. After immersion into simulated body fluid (SBF), the Si ions were gradually released from PKSN into SBF and a weak alkaline environment was created. Antibacterial experiments showed that PKSN exhibited a greater antibacterial activity than that of PEEK. Moreover, compared with PEEK, PKSN significantly promoted adhesion, proliferation, differentiation and expression of osteogenic related genes of the rat bone marrow stromal cells (rBMSCs). In conclusion, the SN coating of PKSN with hierarchical nanostructures exhibited excellent antibacterial activity and cytocompatibility, which would make it a great candidate for orthopedic applications.