文献类型：期刊文献

英文题名：Segmentation of Brain MR Images by Using Fully Convolutional Network and Gaussian Mixture Model with Spatial Constraints

作者：Lai, Jiawei[1];Zhu, Hongqing[1];Ling, Xiaofeng[1]

机构：[1]East China Univ Sci & Technol, Sch Informat Sci & Engn, Shanghai 200237, Peoples R China

年份：2019

卷号：2019

外文期刊名：MATHEMATICAL PROBLEMS IN ENGINEERING

收录：;EI(收录号：20192307000401);WOS:【SCI-EXPANDED(收录号:WOS:000469244000001)】；

基金：This work was supported by the National Nature Science Foundation of China (Grant no. 61872143).

语种：英文

外文关键词：Deep neural networks - Diagnosis - Image segmentation - Gaussian distribution - Clinical research - Tissue - Brain - Magnetic resonance imaging - Convolution

摘要：Accurate segmentation of brain tissue from magnetic resonance images (MRIs) is a critical task for diagnosis, treatment, and clinical research. In this paper, a novel algorithm (GMMD-U) that incorporates the modified full convolutional neural network U-net and Gaussian-Dirichlet mixture model (GMMD) with spatial constraints is presented. The proposed GMMD-U considers the local spatial relationships by assuming that the prior probability obeys the Dirichlet distribution. Specifically, GMMD is applied for extracting brain tissue that has a distinct intensity region and modified U-net is exploited to correct the wrong-classification areas caused by GMMD or other conventional approaches. The proposed GMMD-U is designed to take advantage of the statistical model-based segmentation techniques and deep neural network. We evaluate the performance of GMMD-U on a publicly available brain MRI dataset by comparing it with several existing algorithms, and the results reported reveal that the proposed framework can accurately detect the brain tissue from MRIs. The proposed learning-based integrated framework could be effective for brain tissue segmentation, which will be helpful for surgeons in brain disease diagnosis.