文献类型：期刊文献

英文题名：A highly efficient approach to vanillin starting from 4-cresol

作者：Jiang, Jian-An[1];Chen, Cheng[1];Guo, Ying[1];Liao, Dao-Hua[1];Pan, Xian-Dao[2,3];Ji, Ya-Fei[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China;[3]Peking Union Med Coll, Beijing 100050, Peoples R China

年份：2014

卷号：16

期号：5

起止页码：2807

外文期刊名：GREEN CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000335005200055)，CCR-EXPANDED(收录号:WOS:000335005200055)】；

基金：We gratefully acknowledge the National Natural Science Foundation of China (Project no. 21176074) and the Research Fund for the Doctoral Program of Higher Education of China (Project no. 20130074110009) for financial support.

语种：英文

摘要：A highly efficient approach to the famous flavor and fragrance compound vanillin has been developed starting from 4-cresol with the attention focused on improving the sustainability of all the reactions. The approach involves a three-step sequence of the quasi-quantitative selective clean oxybromination of 4-cresol, the high-yield selective aerobic oxidation of 2-bromo-4-cresol, and the quantitative methoxylation of 3-bromo-4-hydroxybenzaldehyde with the recovery of pure methanol. Herein, the pivotal oxidation and methoxylation reactions are logically investigated and developed into two concise methodologies. As a green alternative, the approach holds significant value for the sustainable manufacturing of vanillin.