文献类型：期刊文献

英文题名：Water-Insensitive Synthesis of Poly-β-Peptides with Defined Architecture

作者：Zhou, Min[1];Xiao, Ximian[1];Cong, Zihao[1];Wu, Yueming[1];Zhang, Wenjing[1];Ma, Pengcheng[1];Chen, Sheng[1];Zhang, Haodong[1];Zhang, Danfeng[1];Zhang, Donghui[1];Luan, Xiangfeng[2];Mai, Yiyong[2];Liu, Runhui[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Key Lab Ultrafine Mat, Minist Educ,Res Ctr Biomed Mat,Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai Key Lab Elect Insulat & Thermal Ageing, Shanghai 200240, Peoples R China

年份：2020

卷号：59

期号：18

起止页码：7240

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20201108285937);WOS:【SCI-EXPANDED(收录号:WOS:000526818900042)】；

语种：英文

外文关键词：polymerization; poly-beta-peptides; secondary structure; water-insensitive polymerization; beta-NTA

摘要：Biocompatible and proteolysis-resistant poly-beta-peptides have broad applications and are dominantly synthesized via the harsh and water-sensitive ring-opening polymerization of beta-lactams in a glovebox or using a Schlenk line, catalyzed by the strong base LiN(SiMe3)(2). We have developed a controllable and water-insensitive ring-opening polymerization of beta-amino acid N-thiocarboxyanhydrides (beta-NTAs) that can be operated in open vessels to prepare poly-beta-peptides in high yields, with diverse functional groups, variable chain length, narrow dispersity and defined architecture. These merits imply wide applications of beta-NTA polymerization and resulting poly-beta-peptides, which is validated by the finding of a HDP-mimicking poly-beta-peptide with potent antimicrobial activities. The living beta-NTA polymerization enables the controllable synthesis of random, block copolymers and easy tuning of both terminal groups of polypeptides, which facilitated the unravelling of the antibacterial mechanism using the fluorophore-labelled poly-beta-peptide.