文献类型：期刊文献

英文题名：Cationic-Catalyst Strategy Enabling Ultrafast and Controlled Polymerization and Efficient Depolymerization Toward a Circular Polymer Economy

作者：Chen, Kang[1,2,3];Wu, Yueming[1,2,4];Chen, Minzhang[2,4];Huang, Xinqi[2,4];Zou, Jingcheng[2,4];Chen, Xin[4];Liu, Runhui[1,2,3,4,5,6]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Engn Res Ctr Biomed Mat,Shanghai Frontiers Sci Ctr, Sch Mat Sci & Engn,Minist Educ,Key Lab Ultrafine M, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Suzhou 215163, Peoples R China;[4]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[5]Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai 200438, Peoples R China;[6]Shanghai Shyndec Pharmaceut Co Ltd, 378 Jian Lu Rd, Shanghai 201203, Peoples R China

年份：2025

卷号：64

期号：52

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20254519457593);WOS:【SCI-EXPANDED(收录号:WOS:001607987800001)】；

基金：This research was supported by the National Natural Science Foundation of China (No. 22475069, T2325010, 52203162, 52361165622), Chinese Academy of Sciences Project for Young Scientists in Basic Research (Grant No. YSBR-111), the Science and Technology Innovation Action Plan Computational Biology Program (24JS2830400), the Fundamental Research Funds for the Central Universities (No. JKVD1251029, JKD01251701), Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission). The authors thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization for studies reviewed in this manuscript. The authors also thank the staff members of the Mass Spectrometry System at the National Facility for Protein Science in Shanghai (NFPS), Zhangjiang Lab, China for providing technical support and assistance in data collection and analysis.

语种：英文

外文关键词：Amino acid polymer; Cationic-catalyst strategy; Circular polymer economy; NCA polymerization; Ultrafast and controlled polymerization

摘要：The development of chemically recyclable polymers is considered one of the ideal solutions to alleviate the growing polymer waste. Fast, controlled synthesis and closed-loop recycling of amino acid (AA) polymers, as an important class of polyamides, are highly important for applications and circular polymer economy. Strong base-initiated N-carboxyanhydrides (NCAs) polymerization can prepare AA polymers very quickly, however, has the long-standing challenge of poor molecular weight controllability and numerous side reactions. Herein, we develop a highly efficient cationic-catalyst strategy that enables both "ultrafast, controlled AA polymer synthesis" and "closed-loop AA polymer recycling". This robust and easily scalable cationic-catalyst strategy is compatible with various organic strong bases as initiators, and enables the synthesis of molecular weight well-controlled AA polymers on a hectogram scale (similar to 120 g) within minutes. Moreover, the cationic catalyst facilitates the efficient depolymerization of AA polymers into environmentally friendly amino acids, with a recovery rate of 85.9%. In addition, the catalyst itself can be recycled quantitatively. In short, the highly efficient cationic-catalyst strategy implies practical and promising applications in polymerization and depolymerization chemistry, demonstrating great potential for the circular polymer economy and sustainable management of polymer waste.