文献类型：期刊文献

英文题名：Preparation and characterization of bioactive mesoporous wollastonite - Polycaprolactone composite scaffold

作者：Wei, Jie[1,2];Chen, Fangping[1];Shin, Jung-Woog[2];Hong, Hua[1];Dai, Chenglong[1];Su, Jiancan[3];Liu, Changsheng[1]

机构：[1]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]Inje Univ, Dept Biomed Engn, Gimhae 621749, Gyeongnam, South Korea;[3]Second Mil Med Univ, Dept Orthopaed, Changhai Hosp, Shanghai 200433, Peoples R China

年份：2009

卷号：30

期号：6

起止页码：1080

外文期刊名：BIOMATERIALS

收录：;EI(收录号：20085211815926);WOS:【SCI-EXPANDED(收录号:WOS:000262750300011)】；

基金：The authors appreciate financial support from the National Science Foundation for Distinguished Young Scholars of China (Grant No.20425621), the Major State Basic Research Program of China (No. 2005CCA01000), Shanghai Pujiang Program (2008), Shanghai Leading Academic Discipline Project (13502) and Nano special program of Science and Technology Development of Shanghai (No. 0852nm02700).

语种：英文

外文关键词：Mesoporous wollastonite; Composite scaffold; Hydrophilicity; Bioactivity; Cell attachment and proliferation

摘要：A well-defined mesoporous structure of wollastonite with high specific surface area was synthesized using surfactant P123 (triblock copolymer) as template, and its composite scaffolds with poly(E-caprolactone) (PCL) were fabricated by a simple method of solvent casting-particulate leaching. The measurements of the water contact angles suggest that the incorporation of either mesoporous wollastonite (m-WS) or conventional wollastonite (c-WS) into PCL could improve the hydrophilicity of the composites, and the former was more effective than the later. The bioactivity of the composite scaffold was evaluated by soaking the scaffolds in a simulated body fluid (SBF) and the results show that the m-WS/PCL composite (m-WPC) scaffolds can induce a dense and continuous layer of apatite after soaking for 1 week, as compared with the scattered and discrete apatite particles on the c-WS/PCL composite (c-WPC) scaffolds. The m-WPC had a significantly enhanced apatite-forming bioactivity compared with the c-WPC owing to the high specific surface area and pore volume of m-WS. In addition, attachment and proliferation of MG(63) cells on m-WPC scaffolds were significantly higher than that of c-WPC, revealing that m-WPC scaffolds had excellent biocompatibility. Such improved properties of m-WPC should be helpful for developing new biomaterials and may have potential use in hard tissue repair. 2008 (C) Elsevier Ltd. All rights reserved.