文献类型：期刊文献

英文题名：A Near-Infrared Organoplatinum(II) Metallacycle Conjugated with Heptamethine Cyanine for Trimodal Cancer Therapy

作者：Huang, Baoxuan[1];Liu, Xi[2];Yang, Guoliang[1];Tian, Jia[1];Liu, Zhiyong[1];Zhu, Yucheng[1];Li, Xiaopeng[3];Yin, Guangqiang[4];Zheng, Wei[2];Xu, Lin[2];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China;[3]Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen 518055, Peoples R China;[4]Univ S Florida, Dept Chem, Tampa, FL 33620 USA

年份：2022

卷号：4

期号：6

起止页码：2090

外文期刊名：CCS CHEMISTRY

收录：WOS:【ESCI(收录号:WOS:000810728900026)】；

基金：This work was financially supported by the National Natural Science Foundation of China (nos. 21875063, 21922506, and 21871092) and the Science and Technology Commission of Shanghai Municipality for the Shanghai International Cooperation Program (no. 19440710600).

语种：英文

外文关键词：near-infrared; metallacycle; cyanine; phototherapy; chemotherapy

摘要：Discrete Pt(II) metallacycles have attracted particular attention for the chemotherapeutic treatment of cancer. However, a single chemotherapy cannot simultaneously balance efficiency and safety because the continuous administration throughout the entire therapy period will lead to inefficient therapy and potentially long-term systemic toxicity. Therefore, the development of a novel organoplatinum(II) metalla-cycle with multimodal treatment capabilities is urgently needed to overcome these issues. Herein, a discrete Pt(II) metallacycle (SCY) bearing the near-infrared (NIR) photosensitizer heptamethine cyanine was fabricated and further encapsulated by amphiphilic 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy(polyethyleneglycol) (DSPEmPEG) to form P@SCY nanoparticles. Heptamethine cyanine, which has excellent photoconversion efficiency, can generate reactive oxygen species (ROS) and heat simultaneously, and the cyanine moiety can target mitochondria in cancer cells due to their quaternary ammonium salt cations, which improve the effect of phototherapy. Due to its excellent phototherapy and chemotherapy properties, P@SCY exhibited remarkable trimodal therapeutic effects [chemo-/ photodynamic therapy (PDT)/photothermal therapy (PTT)] against cancer cells (HepG2 cells, MCF-7 cells, and 4T1 cells) in vitro. Furthermore, in vivo results also confirmed thatP@SCY had superior antitumor properties with minimal side effects in the 4T1 tumor model. Thiswork presents a practicable approach to develop a multifunctional organoplatinum(II) metallacycle for multimodal tumor therapy. [GRAPHICS]