文献类型：期刊文献

中文题名：合成生物学改造微生物及生物被膜用于重金属污染检测与修复

英文题名：A Review on Bioremediation and Detection of Heavy Metal Pollution by Synthetic Biological Engineered Microorganisms and Biofilms

作者：常璐[1];黄娇芳[1,2];董浩[1];周斌辉[3];朱小娟[1];庄英萍[1]

机构：[1]华东理工大学,生物反应器工程国家重点实验室,上海200237;[2]上海科技大学物质科学与技术学院,上海201210;[3]上海市生态环境局执法总队,上海200235

年份：2021

卷号：41

期号：1

起止页码：62

中文期刊名：中国生物工程杂志

外文期刊名：China Biotechnology

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：上海市自然科学基金(19ZR1477100);国家自然科学基金(31872728);国家重点研发计划(2020YFA0908900)资助项目。

语种：中文

中文关键词：重金属污染;生物修复;合成生物学;微生物;生物被膜

外文关键词：Heavy metal pollution;Bioremediation;Synthetic biology;Microorganisms;Biofilms

摘要：随着工业化进程不断加快,重金属污染日益加剧,尤其是水体的重金属污染,已严重威胁人类健康,迫切需要进行有效的污染修复。相比传统物理和化学修复,生物修复具有绿色环保和可持续性的特点。因为微生物生长繁殖迅速、生物被膜具有动态可调节和环境适应性好等特点,使其能更好耐受胁迫环境,在环境修复中有重要作用。合成生物学改造微生物及生物被膜用于环境污染生物修复近年兴起,成为未来重要的发展方向。主要概述了重金属污染的微生物修复机理和方法,结合可编程微生物被膜的最新研究成果,重点介绍了合成生物学改造微生物及生物被膜的分类与功能应用,以及在重金属铅、汞和镉等污染修复中的研究进展,讨论了重金属污染生物修复的发展方向。
With the development of industrialization, heavy metal pollution has become a severe environmental hazard,in particular its pollution to water systems and consequently endangering human health,making its remediation an urgent issue. Compared with traditional physical and chemical remediation,bioremediation is green and sustainable. Microorganisms and microbial biofilms play an important role in bioremediation due to their rapid growth,intrinsic nature for dynamic adaption to environments and consequent tolerance to environmental stresses. Synthetic biology has provided a methodology for engineering and reprograming microorganisms and biofilms with robustness for more efficient degradation of environmental pollutants including heavy metals. This review summarizes the current status of heavy metal pollution,the bioremediation mechanism and research progress of microbial remediation,with a focus on the development of functional biofilms engineered by synthetic biology and their applications in bioremediation for heavy metal Pb,Hg,Cd and others. At the end,this review highlights the perspectives for bioremediation of heavy metal pollution.