文献类型：期刊文献

英文题名：Electrochemically Induced Desulfurization of Thioureas for the Synthesis of Substituted 5-Aminotetrazoles

作者：Yu, Xiao[1,2];Hao, Liqiang[1,2];Liu, Xian[1,2];Jin, Shengkui[1,2];Liu, Yiping[3];Ji, Yafei[1,2]

机构：[1]Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai, Peoples R China;[3]Chongqing Med & Pharmaceut Coll, Sch Pharm, Chongqing, Peoples R China

年份：2024

卷号：366

期号：18

起止页码：3888

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001295451400001)，CCR-EXPANDED(收录号:WOS:001295451400001)】；

语种：英文

外文关键词：Addition-cyclization; Desulfurization; Electrosynthesis; Substituted 5-aminotetrazoles

摘要：A one-pot method has been developed for synthesizing diverse substituted 5-aminotetrazoles via the electrochemically induced desulfurizative addition-cyclization of thioureas with azidotrimethylsilane. This methodology enables the construction of C-N and N-N bonds under mild reaction conditions without transition metal catalysts or external oxidizing agents. The applicability of this approach is demonstrated by its broad substrate scope, compatibility with various functional groups, scalability to gram-scale synthesis, and practicality evidenced by the synthesis of an antibacterial agent. image