文献类型：期刊文献

英文题名：Enantioselective organocatalytic Michael addition of isorhodanines to α,β-unsaturated aldehydes

作者：Wu, Shanchao[1];Li, Yu[1];Zhang, Yongqiang[1,2];Fang, Kun[1];Dong, Guoqiang[1];Liu, Na[1];Miao, Zhenyuan[1];Yao, Jianzhong[1];Wang, Wei[2,3];Zhang, Wannian[1];Sheng, Chunquan[1]

机构：[1]Second Mil Med Univ, Sch Pharm, Dept Med Chem, 325 Guohe Rd, Shanghai 200433, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[3]Univ New Mexico, Dept Chem & Chem Biol, MSC03 2060, Albuquerque, NM 87131 USA

年份：2016

卷号：14

期号：16

起止页码：3926

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20162202452533);WOS:【SCI-EXPANDED(收录号:WOS:000374786500010)】；

基金：We are grateful for financial support from the 863 Hi-Tech Program of China (2014AA020525 to C.S.) and the National Natural Science Foundation of China (81573283, C.S. and 21372073 and 21572055, W.W.).

语种：英文

外文关键词：Addition reactions - Aldehydes

摘要：The Michael reaction of substituted isorhodanines with alpha,beta-unsaturated aldehydes in the presence of a catalytic amount of a chiral secondary amine is presented. This transformation proceeds in good to high yields furnishing the corresponding 4,5-disubstituted isorhodanine adducts in good to excellent enantioselectivities.