文献类型：期刊文献

英文题名：Dual-Enzyme-Loaded Multifunctional Hybrid Nanogel System for Pathological Responsive Ultrasound Imaging and T2-Weighted Magnetic Resonance Imaging

作者：Wang, Xia[1,2];Niu, Dechao[3];Li, Pei[4];Wu, Qing[1,2];Bo, Xiaowan[4];Liu, Boji[4];Bao, Song[1,2];Su, Teng[1,2];Xu, Huixiong[4];Wang, Qigang[1,2]

机构：[1]Tongji Univ, Dept Chem, Shanghai 200092, Peoples R China;[2]Tongji Univ, Adv Res Inst, Shanghai 200092, Peoples R China;[3]E China Univ Sci & Technol, Sch Mat Sci & Engn, Lab Low Dimens Mat Chem, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[4]Tongji Univ, Peoples Hosp 10, Shanghai Peoples Hosp 10, Dept Med Ultrasound, Shanghai 200072, Peoples R China

年份：2015

卷号：9

期号：6

起止页码：5646

外文期刊名：ACS NANO

收录：;EI(收录号：20152600974636);WOS:【SCI-EXPANDED(收录号:WOS:000356988500004)】；

基金：This work was financially supported by the National Natural Science Foundation of China (51402215, 21274111, 81371570, 51473123), the Program for New Century Excellent Talents in University of Ministry of Education of China (NECT-11-0386), China Postdoctoral Science Foundation (2014M550245), Shanghai Postdoctoral Science Foundation (14R21411200), and the Recruitment Program of Global Experts.

语种：英文

外文关键词：hybrid nanogels; pathological responsiveness; ultrasound imaging; magnetic resonance imaging

摘要：A dual-enzyme-loaded multifunctional hybrid nanogel probe (SPIO@GCS/acryl/biotin-CAT/SOD-gel, or SGC) has been developed for dual-modality pathological responsive ultrasound (US) imaging and enhanced T-2-weighted magnetic resonance (MR) imaging. This probe is composed of functionalized superparamagnetic iron oxide particles, a dual enzyme species (catalase and superoxide dismutase), and a polysaccharide cationic polymer glycol chitosan gel. The dual-modality US/MR imaging capabilities of the hybrid nanogel for responsive US imaging and enhanced T-2-weighted MR imaging have been evaluated both in vitro and in vivo. These results show that the hybrid nanogel SGC can exhibit efficient dual-enzyme biocatalysis with pathological species for responsive US imaging. SEC also demonstrates increased accumulation in acidic environments for enhanced T-2-weighted MR imaging. Further research on these nanogel systems may lead to the development of more efficient US/MR contrast agents.