文献类型：期刊文献

英文题名：Electro-assembly of a dynamically adaptive molten fibril state for collagen

作者：Lei, Miao[1];Qu, Xue[1,5];Wan, Haoran[1];Jin, Dawei[4];Wang, Shijia[1];Zhao, Zhiling[2,3];Yin, Meng[4];Payne, Gregory F.[2,3];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Inst Biosci & Biotechnol Res, 5118 A James Clark Hall, College Pk, MD 20742 USA;[3]Robert E Fischell Biomed Device Inst, 5118 A James Clark Hall, College Pk, MD 20742 USA;[4]Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Sch Med, Dept Cardiothorac Surg, 1678 Dong Fang Rd, Shanghai 200127, Peoples R China;[5]East China Univ Sci & Technol, Shanghai Frontier Sci Ctr Optogenet Tech Cell Met, Shanghai 200237, Peoples R China

年份：2022

卷号：8

期号：5

外文期刊名：SCIENCE ADVANCES

收录：;EI(收录号：20220611608645);WOS:【SCI-EXPANDED(收录号:WOS:000750618100013)】；

基金：This research was supported by the National Natural Science Foundation of China (31922041, 51621002, and 11932012), the Science and Technology Innovation Project and Excellent Academic Leader Project of Shanghai Science and Technology Committee (21S31901500, 21XD1421100), the Fundamental Research Funds for the Central Universities (JKVD1211032 and JKVD1211002), and U.S. National Science Foundation (CBET-1932963).

语种：英文

外文关键词：Biomedical engineering

摘要：Collagen is a biological building block that is hierarchically assembled into diverse morphological structures that, in some cases, is dynamically adaptive in response to external cues and in other cases forms static terminal structures. Technically, there is limited capabilities to guide the emergence of collagen's hierarchical organization to recapitulate the richness of biological structure and function. Here, we report an electro-assembly pathway to create a dynamically adaptive intermediate molten fibril state for collagen. Structurally, this intermediate state is composed of partially aligned and reversibly associating fibrils with limited hierarchical structure. These molten fibrils can be reversibly reconfigured to offer dynamic properties such as stimuli-stiffening, stimuli-contracting, self-healing, and self-shaping. Also, molten fibrils can be guided to further assemble to recapitulate the characteristic hierarchical structural features of native collagen (e.g., aligned fibers with D-banding). We envision that the electro-assembly of collagen fibrils will provide previously unidentified opportunities for tailored collagen-based biomedical materials.