文献类型：期刊文献

英文题名：Asymmetric Vinylogous Michael/Oxa-Michael Tandem Reaction between β,γ-Unsaturated Amides and Isatin-Derived β,γ-Unsaturated α-Ketoesters

作者：Xu, Shan-Shan[1,2];Li, Zi-Yu[1,2];Liu, Meng-Yu[1,2];Sha, Feng[1,2];Wu, Xin-Yan[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2024

卷号：89

期号：23

起止页码：17425

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20244717405676);WOS:【SCI-EXPANDED(收录号:WOS:001356520600001)】；

基金：We are grateful for the financial support from Shanghai Zhuodao Investment Management Co., Ltd.

语种：英文

外文关键词：Enantioselectivity

摘要：An organocatalytic asymmetric vinylogous Michael/oxa-Michael tandem reaction between beta,gamma-unsaturated pyrazoleamides and isatin-derived beta,gamma-unsaturated ketoesters has been developed with excellent regio-, diastereo-, and enantioselectivities. The methodology provides an effective approach to construct enantiomerically pure 3,4 '-pyranyl spirooxindole derivatives containing three contiguous chiral centers. Moreover, the transformations of the chiral products, including the removal and reduction of the pyrazole group, have been investigated.