文献类型：期刊文献

英文题名：Dual-Sensitive On-Off Switch in Liposome Bilayer for Controllable Drug Release

作者：Zhang, Xueru[1];Lei, Bin[1];Wang, Yizhou[1];Xu, Shouhong[1];Liu, Honglai[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China

年份：2019

卷号：35

期号：15

起止页码：5213

外文期刊名：LANGMUIR

收录：;EI(收录号：20191706816755);WOS:【SCI-EXPANDED(收录号:WOS:000465190000013)】；

基金：Financial support for this work was provided by the National Natural Science Foundation of China (no. 21776071) and the National Natural Science Foundation of China for Innovative Research Groups (no. 51621002).

语种：英文

外文关键词：Targeted drug delivery - Controlled drug delivery - Irradiation - Block copolymers - Ultraviolet visible spectroscopy - Light scattering

摘要：To improve the controllability of drug release from liposome, a series of pH- and photosensitive block copolymers C7H15-AZO-b-PDPA(n)-b-mPEG were designed and served as an on-off switch in the liposome bilayer. The functional properties of liposomes were studied by dynamic light scattering, fluorophotometry, UV-vis spectroscopy, and fluorescence spectrophotometry. The liposomes with or without copolymer were relatively uniform in size. Their membrane stability was improved obviously after inserting copolymer under pH 7.4, but it decreased in an acidic environment and caused a large amount of drug release. Meanwhile, UV irradiation could also result in more drug release because of the photoisomerization of the azobenzene (AZO) group. Furthermore, intermittent drug-release experiments showed that the PDPA blocks could reversibly get in and out of the liposome bilayer and ultimately realized the complete drug release. All results suggested that the designed copolymers could be inserted into liposome bilayer through self-assembly and could act as a switch for controllable drug release.