文献类型：专利

英文题名：Rapamycin sustained-release nano-microspheres comprise linear-dendritic polyethylene glycol monomethyl ether-dendritic-poly-L-lactide

作者：CHENG S;GUO R;RONG Z;HUI Z;YANG L

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY

申请号：CN105193732-A

申请日：2014-06-05

公开日：2015-12-30

语种：英文

收录：DERWENT

摘要：NOVELTY - Rapamycin sustained-release nano-microspheres comprise linear-dendritic polyethylene glycol monomethyl ether-dendritic-poly-L-lactide. USE - Rapamycin sustained-release nano-microspheres. ADVANTAGE - The microspheres have maximum drug carrying capacity of 45%, encapsulation rate of more than 75%, long-acting sustained release characteristic, and less toxic and side effects. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for preparation of nano-microspheres comprising dissolving rapamycin and polyethylene glycol monomethyl ether-dendritic-poly-L-lactide in inner phase solvent as oil phase; carrying out dialysis treatment with outer phase solvent; evaporating solvent to get drug-loaded micelle solution; and separating micelles precipitate.