文献类型：期刊文献

英文题名：Facile Synthesis of 4-(Trifluoromethyl)-1H-isochromenes from Alkynols

作者：Ji, Xiao Yue[1,2];Siyang, Hai Xiao[1,2];Liu, Kai[1,2];Jiao, Jia Jun[1,2];Liu, Pei Nian[1,2]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Inst Fine Chem, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2016

卷号：5

期号：2

起止页码：240

外文期刊名：ASIAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000370450600011)，CCR-EXPANDED(收录号:WOS:000370450600011)】；

基金：This work was supported by the National Natural Science Foundation of China (project nos. 21172069, 21190033, 21421004, and 21372072), the Basic Research Program of the Shanghai Committee of Sci. & Tech. (project no. 13M1400802), NCET (NCET-13-0798), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：cyclization; heterocycles; isochromenes; Togni's reagent; trifluoromethylation

摘要：Isochromene derivatives are important structural motifs found in various biologically active compounds as well as important natural products. A method to generate CF3-containing isochromene derivatives has been developed, which gives moderate to good yields by using Togni's reagent as the trifluoromethyl source. The key step involves alkynol cyclization and subsequent trapping by a reactive electrophilic trifluoromethyl species generated insitu from Togni's reagent.