文献类型：期刊文献

英文题名：Preparation of core-shell magnetic nano-upconversion materials and its targeting effect

作者：Li, Na[1];Zhao, Yue[1];Cheng, Chao[2];Yang, Yuxiang[1];Yuan, Hongming[3];Carlini, Riccardo[4]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Second Mil Med Univ, Changhai Hosp, Dept Nucl Med, Shanghai 200237, Peoples R China;[3]Jilin Univ, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Jilin, Peoples R China;[4]Genoa Univ, Chem & Ind Chem Dept, I-16146 Genoa, Italy

年份：2018

卷号：227

起止页码：44

外文期刊名：MATERIALS LETTERS

收录：;EI(收录号：20182105219692);WOS:【SCI-EXPANDED(收录号:WOS:000436420200012)】；

语种：英文

外文关键词：Magnetic nanoparticles; Up-conversion; Fluorescence; Targeting

摘要：In this paper, magnetic upconversion Fe3O4@SiO2@NaGdF4:Yb,Er (UCP) composite particles were prepared by Fe3O4@SiO2-NH2 nanoparticles reacting with NaGdF4:Yb, Er modified by alpha-bromoisobutyric acid for the first time. The products were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), EDS and fluorescence spectrum. The results show that UCP composite nanoparticles have upconversion fluorescence emission peaks as NaGdF4:Yb,Er but weaker emission intensity. In contrast to NaGdF4:Yb,Er@Fe3O4 particles, UCP composite nanoparticles have better fluorescence luminescence properties, but poor magnetic properties. Biological distribution and magnetic nano-uptake of radioactive in mouse show nanomagnetic UCP particles loaded with drugs can be accumulated in the tumor site of spleen and pancreas by magnetic controlled targeting, in order to achieve drug magnetic targeted therapy. (C) 2018 Elsevier B.V. All rights reserved.