文献类型：期刊文献

中文题名：Diastereoselective synthesis of functionalized tetrahydro-γ-carbolines via a[3+3] cycloaddition of 2,2’-diester aziridines with β-(indol-2-yl)-α,β-unsaturated ketones

作者：Xuejie Zou[1];Yangzi Liu[1];Shaojing Shang[1];Wulin Yang[1];Weiping Deng[1]

机构：[1]Shanghai Key Laboratory of New Drug Design and School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China

年份：2020

卷号：31

期号：5

起止页码：1293

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2019_2020】；PubMed;

基金：supported by the National Natural Science Foundation of China(No.21772038);the China Postdoctoral Science Foundation(No.2018M632037)。

语种：英文

中文关键词：Aziridine;Tetrahydro-γ-carboline;[3+3]cycloaddition;Sc(OTf)3;Diastereoselectivity

摘要：A Sc(OTf)3-catalyzed[3+3]cycloaddition of 2,2’-diester aziridines withβ-(indol-2-yl)-α,β-unsaturated ketones was developed,affording polysubstituted tetrahydro-y-carbolines in single diastereoisomers in good to excellent yields.