文献类型：期刊文献

英文题名：Effects of pore structure of mesoporous silicas on the electrochemical properties of hemoglobin

作者：Li, Jinxia;Xiong, Zhiying;Zhou, Lihui[1];Han, Xia;Liu, Honglai

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China

年份：2010

卷号：130

期号：1-3

起止页码：333

外文期刊名：MICROPOROUS AND MESOPOROUS MATERIALS

收录：;EI(收录号：20100612698022);WOS:【SCI-EXPANDED(收录号:WOS:000275702600046)】；

基金：This work is supported by the National Natural Science Foundation of China (Project Nos. 20736002, 20776045), Program for Changjiang Scholars and Innovative Research Team in University (No. IRT0721).

语种：英文

外文关键词：Hemoglobin; Mesoporous silicas; Porous structure; Direct electron transfer

摘要：Effects of pore structure of mesoporous silicas (MPS) on the direct electron transfer of hemoglobin (Hb) were investigated. MCM-41 and SBA-15 were used to supply ID channel and hexagonal mesoporous structure with the average pore diameters of 3.2 and 6.9 nm, respectively, while MCF was used to supply 3D and caged mesoporous network structure with the average pore diameter of 15.7 nm. Hb was immobilized by the physical adsorption method without significant denaturation and have the saturated binding amounts of 15.8, 240.0 and 325.7 mg g(-1) for MCM-41, SBA-15 and MCF, respectively. The electrochemical properties of Hb/MPS/GC modified electrode were studied by cyclic voltammetry (CV). A couple of redox peaks were observed at Hb/SBA-15/CC and Hb/MCF/GC, while no obvious redox peak was found at Hb/MCM-41/GC modified electrode because Hb molecule could not enter into the channels of MCM-41. The CV signal of Hb/MCF/GC is about 2x as large as that of Hb/SBA-15/GC electrode when the same amount of Hb was immobilized in the pores of MCF and SBA-15, which suggests that the 3D porous structure may be the key factor for promoting the electron transfer of Hb. (C) 2009 Elsevier Inc. All rights reserved.