文献类型：期刊文献

英文题名：Characteristics and mechanisms of resorption in lumbar disc herniation

作者：Yu, Pengfei[1];Mao, Feng[2];Chen, Jingyun[3,4];Ma, Xiaoying[3,4];Dai, Yuxiang[1];Liu, Guanhong[1];Dai, Feng[1];Liu, Jingtao[1]

机构：[1]Nanjing Univ Chinese Med, Suzhou TCM Hosp, Dept Orthopaed Surg, Suzhou 215009, Peoples R China;[2]Kunshan Integrated TCM & Western Med Hosp, Dept Orthopaed Surg, Suzhou 215332, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2022

卷号：24

期号：1

外文期刊名：ARTHRITIS RESEARCH & THERAPY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000843503200001)】；

基金：This research was funded by National Natural Science Foundation of China (NO. 82004393; NO. 82074467) and National Natural Science Foundation of Jiangsu, China (No. BK20190191; NO. BK20201180).

语种：英文

外文关键词：Lumbar disc herniation; Autoimmune response; Inflammation; Macrophages; Angiogenesis

摘要：Lumbar disc herniation (LDH) can be spontaneously absorbed without surgical treatment. However, the pathogenesis and physiological indications for predicting protrusion reabsorption are still unclear, which prevents clinicians from preferentially choosing conservative treatment options for LDH patients with reabsorption effects. The purpose of this review was to summarize previous reports on LDH reabsorption and to discuss the clinical and imaging features that favor natural absorption. We highlighted the biological mechanisms involved in the phenomenon of LDH reabsorption, including macrophage infiltration, inflammatory responses, matrix remodeling, and neovascularization. In addition, we summarized and discussed potential clinical treatments for promoting reabsorption. Current evidence suggests that macrophage regulation of inflammatory mediators, matrix metalloproteinases, and specific cytokines in intervertebral disc is essential for the spontaneous reabsorption of LDH.