文献类型：期刊文献

英文题名：Calcium content mediated hemostasis of calcium-modified oxidized microporous starch

作者：Yu, Junxia[1,2];Su, Huantong[2];Wei, Shuda[1,2];Chen, Fangping[2,3];Liu, Changsheng[1,2,3]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China

年份：2018

卷号：29

期号：14

起止页码：1716

外文期刊名：JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

收录：;EI(收录号：20182505337091);WOS:【SCI-EXPANDED(收录号:WOS:000448728400005)】；

语种：英文

外文关键词：Calcium; calcium-modified oxidized microporous starch; chemical hemostatic mechanism; oxidized microporous starch

摘要：Blood coagulates are closely related to calcium ions (coagulation factor IV), and calcium-doped biomaterials have been reported to be effective in hemostasis. However, the effects exerted by calcium on hemostatic agents have not been previously investigated. The aims of this work were to develop calcium-modified oxidized microporous starch (CaOMS) with controllable calcium contents and to explore the relationship between calcium content and hemostatic effects. The results showed that low calcium content promoted coagulation, while high calcium content inhibited coagulation. CaOMS3 with 2.2mg/g calcium content was optimal because of its excellent water absorption performance that enhanced physical coagulation, the rapid initiationof coagulation cascade reactions, and the enhanced chemical coagulation by RBC aggregation and platelet activation. The synergistic effects of chemical activation and physical absorption endowed CaOMS with the potential to control internal organ bleeding. These results suggested that CaOMS may be a promising hemostatic agent with wide spread applications.