文献类型：期刊文献

英文题名：The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinson's Disease Related Protein

作者：Fu, Qing-Shan[1];Song, Ai-Xin[1];Li, Su-Xia[2];Hu, Hong-Yu[1]

机构：[1]Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China;[2]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2009

卷号：16

期号：12

起止页码：1442

外文期刊名：PROTEIN AND PEPTIDE LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000271620200005)】；

基金：The authors thank Dr. Jordi Perez-Tur of Consejo Superior de Investigaciones Cientificas for providing the LRRK2 gene. This work was supported by the grants from the National Basic Research Program of China (2006CB910305, 2006CB806508) and the National Natural Science Foundation of China (30600103, 30670431).

语种：英文

外文关键词：LRRK2; ROC domain; small GTPase; GTP binding; Parkinson's disease

摘要：Mutations in the LRRK2 gene have been implicated in the pathogenesis of Parkinson's disease. This work provides biochemical evidence that the ROC domain of LRRK2 functions as a small GTPase, and the Parkinson's disease-associated mutants do not appear to have reduced GTP hydrolysis activities.