文献类型：期刊文献

英文题名：Rational Biological Interface Engineering: Amyloidal Supramolecular Microstructure-Inspired Hydrogel

作者：Xuan, Qize[1];Wang, Yibing[1];Chen, Chao[1];Wang, Ping[2]

机构：[1]East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[2]Univ Minnesota, Dept Bioprod & Biosyst Engn, St Paul, MN USA

年份：2021

卷号：9

外文期刊名：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY

收录：;EI(收录号：20213210734784);WOS:【SCI-EXPANDED(收录号:WOS:000682997600001)】；

基金：This study was sponsored by the National Natural Science Foundation of China (Grant Nos: 21908059, 41907318, and 21636003), the China Postdoctoral Science Foundation (Grant No: 2019M651419), Shanghai Sailing Program (Grant No: 19YF1410900), the Fundamental Research Funds for the Central Universities (Grant No: 22221818014), the Shanghai Postdoctoral Excellence Program (Grant No: 2018011), supported by the Foundation of State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences (Grant No: GZKF202031), and the Open Funding Project of the State Key Laboratory of Bioreactor Engineering.

语种：英文

外文关键词：amyloid fibrils; hydrogel; self-assembly; tissue engineering; drug delivery

摘要：Amyloidal proteins, which are prone to form fibrillar and ordered aggregates in vivo and in vitro, underlie the mechanism for neurodegenerative disorders and also play essential functions in the process of life. Amyloid fibrils typically adopt a distinctive beta-sheet structure, which renders them with inherent extracellular matrix (ECM)-mimicking properties, such as powerful mechanical strength, promising adhesion, and antibacterial activity. Additionally, amyloidal proteins are a category of programmable self-assembled macromolecules, and their assembly and consequent nanostructure can be manipulated rationally. The above advantages motivate researchers to investigate the potential of amyloidal proteins as a novel type of hydrogel material. Currently, the amyloid-inspired hydrogel has become an emerging area and has been widely applied in a variety of biomedical fields, such as tissue repair, cell scaffolds, and drug delivery. In this review, we focus on the discussion of molecular mechanisms underlying the hydrogenation of amyloidal proteins, and introduce the advances achieved in biomedical applications of amyloid-inspired hydrogels.