文献类型：期刊文献

英文题名：Excited-State Dynamics of Proflavine after Intercalation into DNA Duplex

作者：Zhou, Jie[1];Jia, Yanyan[2];Wang, Xueli[1];Jia, Menghui[1];Pan, Haifeng[1];Sun, Zhenrong[1];Chen, Jinquan[1,3]

机构：[1]East China Normal Univ, State Key Lab Precis Spect, Shanghai 200241, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr,Key La, Shanghai 200237, Peoples R China;[3]Shanxi Univ, Collaborat Innovat Ctr Extreme Opt, Taiyuan 030006, Peoples R China

年份：2022

卷号：27

期号：23

外文期刊名：MOLECULES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000896200700001)】；

语种：英文

外文关键词：excited-state dynamics; proflavine; DNA duplex; femtosecond transient-absorption; fluorescence-quenching

摘要：Proflavine is an acridine derivative which was discovered as one of the earliest antibacterial agents, and it has been proven to have potential application to fields such as chemotherapy, photobiology and solar-energy conversion. In particular, it is well known that proflavine can bind to DNA with different modes, and this may open addition photochemical-reaction channels in DNA. Herein, the excited-state dynamics of proflavine after intercalation into DNA duplex is studied using femtosecond time-resolved spectroscopy, and compared with that in solution. It is demonstrated that both fluorescence and the triplet excited-state generation of proflavine were quenched after intercalation into DNA, due to ultrafast non-radiative channels. A static-quenching mechanism was identified for the proflavine-DNA complex, in line with the spectroscopy data, and the excited-state deactivation mechanism was proposed.