文献类型：期刊文献

英文题名：Microwave-Assisted Copper-Catalyzed Oxidative Cyclization of Acrylamides with Non-Activated Ketones

作者：Zhao, Yaping[1,2];Sharma, Nandini[1];Sharma, Upendra K.[1];Li, Zhenghua[1];Song, Gonghua[2];Van der Eycken, Erik V.[1]

机构：[1]Univ Leuven KU Leuven, Lab Organ & Microwave Assisted Chem LOMAC, Dept Chem, Celestijnenlaan 200F, B-3001 Leuven, Belgium;[2]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2016

卷号：22

期号：17

起止页码：5878

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20161102102639);WOS:【SCI-EXPANDED(收录号:WOS:000374542900013)，CCR-EXPANDED(收录号:WOS:000374542900013)】；

基金：Support was provided by the Research Fund of the University of Leuven (KU Leuven) and the FWO Fund for Scientific Research Flanders (Belgium). U.K.S. and N.S. are thankful to KU Leuven for providing a post-doctoral fellowship. Y.Z. and Z.L. are grateful to the China Scholarship Council (CSC) for providing a doctoral exchange and doctoral scholarship, respectively.

语种：英文

外文关键词：alkenes; copper; ketones; oxindoles; radical addition

摘要：An operationally simple and efficient microwave-assisted protocol for the oxidative cyclization of acrylamide derivatives with non-activated ketones to generate 3,3-disubstituted oxindoles is described. The reaction proceeds by a copper-catalyzed tandem radical addition/cyclization strategy and tolerates a series of functional groups with moderate to excellent yields.