文献类型：期刊文献

英文题名：Complexes of an Anionic Surfactant with Chitosan and Its Hydrophobic Derivatives As Disinfectants against SARS-CoV-2

作者：Shibaev, A. V.[1];Ospennikov, A. S.[1];Kornilaeva, G. V.[2];Larichev, V. F.[2];Fedyakina, I. T.[2];Fu, Lifeng[3];Chen, Zhuo[4];Yang, Yangyang[4];Karamov, E. V.[2,5];Turgiev, Ali S.[2,5];Duan, Liping[6];Liu, Jun[7];Philippova, O. E.[1]

机构：[1]Moscow MV Lomonosov State Univ, Phys Dept, Moscow 119991, Russia;[2]Russian Minist Hlth, Gamaleya Natl Res Ctr Epidemiol & Microbiol, Moscow 123098, Russia;[3]Chinese Acad Sci, CAS Key Lab Pathogen Microbiol & Immunol, Inst Microbiol, Beijing 100101, Peoples R China;[4]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[5]Russian Minist Hlth, Natl Med Res Ctr Phthisiopulmonol & Infect Dis, Moscow 127473, Russia;[6]Chinese Ctr Dis Control & Prevent, Natl Inst Parasit Dis, WHO Collaborating Ctr Trop Dis, NHC Key Lab Parasite & Vector Biol, Shanghai 200025, Peoples R China;[7]Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, NHC Key Lab Biosafety, Beijing 102206, Peoples R China

年份：2023

卷号：65

期号：5

起止页码：504

外文期刊名：POLYMER SCIENCE SERIES A

收录：;EI(收录号：20251218077348);WOS:【SCI-EXPANDED(收录号:WOS:001138419400003)】；

基金：The reported study was funded by the Russian Foundation for Basic Research, National Natural Science Foundation of China (NSFC), and National Council for Scientific and Technological Development (CNPq) (BRICS researchproject 085-ChitoTarCoV; RFBR project no. 20-53-80005); and by the Theoretical Physics and Mathematics Advancement Foundation "BASIS" (A.S. Ospennikov). The authors acknowledge partial support from Moscow State University Program of Development.

语种：英文

外文关键词：anionic disinfectants; SARS-CoV-2; chitosan; hydrophobic modification; polymer/surfactant complexes

摘要：This work is aimed at the preparation of complexes of chitosan and hydrophobically modified (HM) chitosan with an anionic surfactant sodium dodecylbenzene sulfonate (SDBS), and at the study of the virucidal activity of the complexes and their components against SARS-CoV-2. It is shown that the introduction of a sufficient amount (4 mol%) of hydrophobic n-dodecyl side groups provides the activity of HM chitosan against SARS-CoV-2 at moderate concentrations, at which unmodified chitosan and chitosan containing a lower amount of hydrophobic groups do not show any activity. Complexes of HM chitosan with SDBS are prepared, which is proven by fluorescence spectroscopy and isothermal titration calorimetry. It is discovered that HM chitosan/SDBS complex is more active than the polymer without surfactant, and an increase of the amount of hydrophobic groups enhances the activity.