文献类型：期刊文献

中文题名：Drug Design of "Undruggable" Targets

作者：Jie Wang[1];Shiliang Li[1];Honglin Li[1]

机构：[1]Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

年份：2019

卷号：37

期号：5

起止页码：501

中文期刊名：Chinese Journal of Chemistry

外文期刊名：中国化学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2019_2020】；

基金：the National Key Research and Development Program [2016YFA0502304 to H.L.];the National Natural Science Foundation of China (grant 81825020 to H.L., 81803437 to S.L.);the National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China (No. 2018ZX09711002);Shanghai Sailing Program (No. 18YF1405100);National Program for Special Supports of Eminent Professionals and National Program for Support of Top-notch Young Professionals.

语种：英文

中文关键词：reflected;chemotypes;drugs

摘要：Drug innovation is not only reflected in the discovery of new chemotypes of active compounds against existing targets but also more dependent on the innovation of drug targets. Currently, a number of attractive and validated targets could not be targeted pharmacologically. Some have been described as "un druggable''.In this review, we summarized the curre nt situatio n of "undruggable" targets, and the desig n strategies for "un druggable" targets, hoping to provide references for the development of innovative drugs.