文献类型：期刊文献

英文题名：Catalytic Asymmetric Construction of Chiral Hydropyridazines via Conjugate Addition of N-Monosubstituted Hydrazones to Enones

作者：Wu, Wenbin[1];Yuan, Xiaoqian[1];Hu, Juan[1];Wu, Xinxin[1];Wei, Yuan[1];Liu, Zunwu[1];Lu, Junzhu[1];Ye, Jinxing[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China

年份：2013

卷号：15

期号：17

起止页码：4524

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000328864800064)，CCR-EXPANDED(收录号:WOS:000328864800064)】；

基金：This work was supported by the National Natural Science Foundation of China (21272068), the Innovation Program of Shanghai Municipal Education Commission (11ZZ56), and the Fundamental Research Funds for the Central Universities.

语种：英文

摘要：The first example of a highly enantioselective and scalable formal diaza-ene reaction between N-monosubstituted hydrazones and enones catalyzed by a simple chiral primary-second diamine salt has been developed. The catalytic process provides a highly practical and stereoselective synthetic method for chiral hydropyridazines.