文献类型：期刊文献

英文题名：Hypervalent Iodine(III)-Mediated Tosyloxylation of 4-Hydroxycoumarins

作者：Xu, Bowen[1,2];Gao, Yiping[3];Han, Jianwei[1,2];Xing, Zejing[1,2];Zhao, Sihan[1,2];Zhang, Ziyang[1,2];Ren, Runlin[1,2];Wang, Limin[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Shanghai Xuhui Cent Hosp, Shanghai 200031, Peoples R China

年份：2019

卷号：84

期号：16

起止页码：10136

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20193607390485);WOS:【SCI-EXPANDED(收录号:WOS:000481979200027)，CCR-EXPANDED(收录号:WOS:000481979200027)】；

基金：The work was supported by the National Nature Science Foundation of China (NSFC 21772039), National Key Program (2016YFA0200302, Study on application and preparation of aroma nanocomposites), the Fundamental Research Funds for the Central Universities and Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, and Chinese Academy of Sciences.

语种：英文

外文关键词：Drug products

摘要：An efficient approach was developed for synthesis of 3-tosyloxy-4-hydroxycoumarins under mild conditions by using Koser's reagents. The reaction tolerated various functional groups, and the products served as useful aromatic building blocks. Additionally, a plausible mechanism via iodonium ylide was proposed, and the oral anticoagulant Warfarin was synthesized in good yield.