文献类型：期刊文献

中文题名：A general approach to the design of high-performance near-infrared (NIR) D-π-A type fluorescent dyes

英文题名：A general approach to the design of high-performance near-infrared (NIR) D-π-A type fluorescent dyes

作者：Xiao Luo[1];Jin Li[2];Jie Zhao[2];Luyan Gu[2];Xuhong Qian[1,2];Youjun Yang[2]

机构：[1]School of Chemistry and Molecular Engineering, East China Normal University;[2]State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology

年份：2019

卷号：30

期号：4

起止页码：839

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2019_2020】；PubMed;

基金：supported by the National Natural Science Foundation of China (Nos. 21574039 and 21822805);Shanghai Municipal Science and Technology Commission (No. 18DZ1112703)

语种：英文

中文关键词：Near;infrared;Polymethine;cyanine;Fluorescence;Steric;protection;Rigidity

外文关键词：Near infrared;Polymethine cyanine;Fluorescence;Steric protection;Rigidity

摘要：Near infrared(NIR) absorbing and emitting dyes are sought after for their potentials in bioimaging and theranostic applications. They are typically not as stable as dyes absorbing and emitting in the visible spectral range, as the result of a reduced HOMO-LUMO band-gap. Also, they are not as efficient fluorescence emitters due to accelerated internal conversion kinetics. In addition, their large conjugative backbone render them high tendency to form aggregate and low aqueous solubility. In this tutorial, we have described a four-step approach for rational design of organic dyes with an overall high-performance to meet the rigorous requirements of biological applications. Also, some background regarding "NIR" is provided along with some recent breakthroughs of the field.
Near infrared(NIR) absorbing and emitting dyes are sought after for their potentials in bioimaging and theranostic applications. They are typically not as stable as dyes absorbing and emitting in the visible spectral range, as the result of a reduced HOMO-LUMO band-gap. Also, they are not as efficient fluorescence emitters due to accelerated internal conversion kinetics. In addition, their large conjugative backbone render them high tendency to form aggregate and low aqueous solubility. In this tutorial, we have described a four-step approach for rational design of organic dyes with an overall high-performance to meet the rigorous requirements of biological applications. Also, some background regarding "NIR" is provided along with some recent breakthroughs of the field.