文献类型：期刊文献

英文题名：A minor structure modification serendipitously leads to a highly carbapenemase-specific fluorogenic probe

作者：Wang, Jie[1];Xu, Weipan[1];Xue, Shuyuan[1];Yu, Tao[1];Xie, Hexin[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2020

卷号：18

期号：21

起止页码：4029

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20202308797568);WOS:【SCI-EXPANDED(收录号:WOS:000538169500010)】；

基金：We are grateful for financial support from the NSFC-BRICS (81861148020), the NSFC (21472048), the Research Program of State Key Laboratory of Bioreactor Engineering, and the Recruitment Program for Young Professionals.

语种：英文

外文关键词：Amino acids - Carbon

摘要：Reported herein is a fluorogenic probe for the detection of carbapenemase activity. This reagent features carbapenem as an enzyme recognition motif and a carbon-carbon double bond between carbapenem and the fluorophore, exhibiting high specificity to all carbapenemases, including metallo carbapenemases and serine carbapenemases, over other beta-lactamases.