文献类型：期刊文献

英文题名：Redox-Channeling Polydopamine-Ferrocene (PDA-Fc) Coating To Confer Context-Dependent and Photothermal Antimicrobial Activities

作者：Song, Jialin[1];Liu, Huan[1];Lei, Miao[1];Tan, Haoqi[1];Chen, Zhanyi[1];Antoshin, Artem[2];Payne, Gregory F.[3];Qu, Xue[1];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Engn Res Ctr Biomed Mat, Minist Educ,Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]Sechenov Univ, Inst Regenerat Med, Moscow 119991, Russia;[3]Inst Biosyst & Biotechnol Res & Fischell, Dept Bioengn, College Pk, MD 20742 USA

年份：2020

卷号：12

期号：7

起止页码：8915

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20201008254990);WOS:【SCI-EXPANDED(收录号:WOS:000515214300115)】；

基金：The support from the National Natural Science Foundation of China (51621002, 31922041, 11932012, and 51573047), 111 Project (B14018), the Science and Technology Innovation Project of Shanghai Science and Technology Committee (18441908300), and the United States National Science Foundation (DMREF-1435957; ECCS-1807604) is acknowledged.

语种：英文

外文关键词：implant; antibacterial; redox; polydopamine; hydroxy radical; photothermal; chemodynamic therapy

摘要：Microbial disinfection associated with medical device surfaces has been an increasing need, and surface modification strategies such as antibacterial coatings have gained great interest. Here, we report the development of polydopamine-ferrocene (PDA-Fc)-functionalized TiO2 nanorods (Ti-Nd-PDA-Fc) as a context-dependent antibacterial system on implant to combat bacterial infection and hinder biofilm formation. In this work, two synergistic antimicrobial mechanisms of the PDA-Fc coating are proposed. First, the PDA-Fc coating is redox-active and can be locally activated to release antibacterial reactive oxygen species (ROS), especially center dot OH in response to the acidic microenvironment induced by bacteria colonization and host immune responses. The results demonstrate that redox-based antimicrobial activity of Ti-Nd-PDA-Fc offers antibacterial efficacy of over 95 and 92% against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli), respectively. Second, the photothermal effect of PDA can enhance the antibacterial capability upon near-infrared (NIR) irradiation, with over 99% killing efficacy against MRSA and E. coli, and even suppress the formation of biofilm through both localized hyperthermia and enhanced center dot OH generation. Additionally, Ti-Nd-PDA-Fc is biocompatible when tested with model pre-osteoblast MC-3T3 E1 cells and promotes cell adhesion and spreading presumably due to its nanotopographical features. The MRSA-infected wound model also indicates that Ti-Nd-PDA-Fc with NIR irradiation can effectively eliminate bacterial infection and suppress host inflammatory responses. We believe that this study demonstrates a simple means to create biocompatible redox-active coatings that confer context-dependent antibacterial activities to implant surfaces.