文献类型：期刊文献

英文题名：tert-Butyloxycarbonyl-protected amino acid ionic liquids and their application to dipeptide synthesis

作者：Chen, Ming[1];Yu, Xihan[2]

机构：[1]Yantai Univ, Sch Pharm, Qinqquan Rd 30, Yantai 264005, Peoples R China;[2]East China Univ Sci & Technol, Coll Pharm, Meilong Rd 130, Shanghai 200237, Peoples R China

年份：2021

卷号：11

期号：44

起止页码：27603

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20213410813115);WOS:【SCI-EXPANDED(收录号:WOS:000686721400050)】；

基金：We gratefully acknowledge the Shanghai Pujiang Program for funding.

语种：英文

外文关键词：Ionic liquids - Peptides - Amides

摘要：Care should be taken when using amino acid ionic liquids (AAILs) for organic synthesis because of their multiple reactive groups. To expand the applicability of AAILs, we prepared a series of room-temperature ionic liquids derived from commercially available tert-butyloxycarbonyl-protected amino acids (Boc-AAILs). The resulting protected AAILs were used as the starting materials in dipeptide synthesis with commonly used coupling reagents. The distinctive coupling reagent N,N '-diethylene-N ''-2-chloroethyl thiophosphoramide was found to enhance amide formation in the Boc-AAILs without addition of base, giving the dipeptides in satisfactory yields in 15 min.