文献类型：期刊文献

英文题名：Asymmetric syntheses of both enantiomers of amphetamine hydrochloride via bakers' yeast reduction of phenylacetone

作者：Shi, XX; Yao, JZ; Kang, L; Shen, CL; Yi, F

机构：[1]E China Univ Sci & Technol, Fac Chem & Pharmaceut Engn, Shanghai 200237, Peoples R China

年份：2004

期号：10

起止页码：681

外文期刊名：JOURNAL OF CHEMICAL RESEARCH-S

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000226149900011)】；

语种：英文

外文关键词：asymmetric synthesis; amphetamines; bakers' yeast; chiral inversion

摘要：Both enantiomers of amphetamine hydrochloride were stereospecifically synthesised based on bakers' yeast reduction of phenylacetone. A simple and efficient method for the chiral inversion of (S)-1-phenyl-2-propanol 3 to (R)-1-phenyl-2-propanol 8 has been discussed.