文献类型：期刊文献

英文题名：Preparation and characterization of β-cyclodextrin grafted N-maleoyl chitosan nanoparticles for drug delivery

作者：Hou, Xinyu[1,2];Zhang, Wenjuan[2];He, Muye[2];Lu, Yiben[2];Lou, Kaiyan[1];Gao, Feng[1,2,3]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2017

卷号：12

期号：6

起止页码：558

外文期刊名：ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000417609400008)】；

基金：This work was supported by the National Science Foundation of China (No. 21577037) and Shanghai Committee of Science and Technology (No. 17ZR1406600). This work was also sponsored by Science and Technology Commission of Shanghai Municipality (STCSM, contract No. 10DZ2220500) and Shanghai Committee of Science and Technology (grant No. 11DZ2260600).

语种：英文

外文关键词：beta-cyclodextrin; Chitosan; Nanoparticle drug delivery system; Ketoprofen

摘要：beta-cyclodextrin (CD) grafted N-maleoyl chitosan (CD-g-NMCS) with two different degrees of substitution (DS) of N-maleoyl (DS = 21.2% and 30.5%) were synthesized from maleic anhydride and chitosan bearing pendant cyclodextrin (CD-g-CS). CD-g-NMCS based nanoparticles were prepared via an ionic gelation method together with chitosan and CD-g-CS nanoparticles. The size and zeta potential of prepared CD-g-NMCS nanoparticles were 179.2 similar to 274.0 nm and 36.2 similar to 42.4 mV, respectively. In vitro stability test indicated that CD-g-NMCS nanoparticles were more stable in phosphate-buffered saline compared with chitosan nanoparticles. Moreover, a poorly water-soluble drug, ketoprofen (KTP), was selected as a model drug to study the obtained nanoparticle's potentials as drug delivery carriers. The drug loading efficiency of CD-g-NMCS20 nanoparticles were 14.8% for KTP. MTT assay showed that KTP loaded CD-g-NMCS nanoparticles were safe drug carriers. Notably, in vitro drug release studies showed that KTP was released in a sustained-release manner for the nanoparticles. The pharmacokinetic of drug loaded CD-g-NMCS20 nanoparticles were evaluated in rats after intravenous administration. The results of studies revealed that, compared with free KTP, KTP loaded CD-g-NMCS20 nanoparticles exhibited a significant increase in AUC0. 24h and mean residence time by 6.6-fold and 2.9-fold, respectively. Therefore, CD-g-NMCS nanoparticles could be used as a novel promising nanoparticle-based drug delivery system for sustained release of poorly water-soluble drugs. The carboxylic acid groups of the CD-g-NMCS molecule provide convenient sites for further structural modifications including introduction of tissue-or disease-specific targeting groups. (C) 2017 Production and hosting by Elsevier B. V. on behalf of Shenyang Pharmaceutical University. This is an open access article under the CC BY-NC-ND license.