文献类型：期刊文献

英文题名：Saponin-Based Near-Infrared Nanoparticles with Aggregation-Induced Emission Behavior: Enhancing Cell Compatibility and Permeability

作者：Zhang, Jie[1,2];Wang, Qi[1,2];Liu, Jingkang[3];Guo, Zhiqian[1,2];Yang, Jinfeng[4];Li, Qiang[1,2];Zhang, Shaoze[1,2];Yan, Chenxu[1,2];Zhu, Wei-Hong[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Joint Int Res Lab Precis Chem & Mol Engn,Shanghai, Key Lab Adv Mat,Feringa Nobel Prize Scientist Joi, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr,Sch C, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[4]Shihezi Univ, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Coll Chem & Chem Engn, Shihezi 832000, Peoples R China

年份：2019

卷号：2

期号：2

起止页码：943

外文期刊名：ACS APPLIED BIO MATERIALS

收录：EI(收录号：20194007491993);WOS:【ESCI(收录号:WOS:000616368100035)】；

基金：This work was supported by NSFC Science Center Program (21788102) and Creative Research Groups (21421004), National key Research and Development Program (2016YFA0200300 and 2017YFC0906900), NSFC/China (21636002, 21622602, and 81602718), Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), and Fundamental Research Funds for the Central Universities, and Program of Introducing Talents of Discipline to Universities (B16017).

语种：英文

外文关键词：aggregation-induced emission; extending emission; saponin-based micellization; compatibility and permeability

摘要：Fluorescence imaging is critical for physiological activities and cell biology but limited by the poor solubility, cell compatibility, and permeability. Herein, we develop a novel engineering methodology to prepare biocompatible and penetrable aggregation-induced emission (AIE) nanoparticles with the assistance of flash nanoprecipitation (FNP) technology. On the basis of the donor-pi-acceptor (D-pi-A) system, the AIE building block of tricyano-methylene-pyridine (TCM) is fine-tuned to long emission wavelength by modulating the pi-conjugation bridge and electron-donating group, thereby achieving high solid fluorescent quantum yield, near-infrared (NIR) characteristic, large Stokes shift, and excellent photostability. On the basis of the FNP technology, the amphiphilic saponin solution and TCMN-5 in organic solvent are quickly mixed in the multi-inlet vortex mixer (MIVM), followed by saponin-encapsulation of the hydrophobic AIE nucleation with inhibiting further growth of nanoparticles. The biocompatible amphiphilic saponin such as alpha-hederin can encapsulate and micellize the AIE TCM fluorophore for efficient cell imaging. The kinetic FNP technology can not only modulate the uniform diameter size, but also distinctly increase the micelle stability when compared to the conventional thermodynamic self-aggregation method, which provides an alternative opportunity for scale-up preparation of drugs and probes in delivery vehicles.