文献类型：期刊文献

英文题名：Enantioselective Vinylogous Conia-Ene Reaction Catalyzed by a Disilver(I)/Bisdiamine Complex

作者：Zou, Chuncheng[1];Yang, Lei[1];Zhang, Lei[1];Liu, Chengyu[1];Ma, Yueyue[1];Song, Gonghua[2];Liu, Zhen[3];Cheng, Ruihua[3];Ye, Jinxing[1,4]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Shanghai Key Lab New Drug Design,Sch Pharm, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Chem & Biol, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China;[4]Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China

年份：2021

卷号：11

期号：12

起止页码：6865

外文期刊名：ACS CATALYSIS

收录：;EI(收录号：20212610551493);WOS:【SCI-EXPANDED(收录号:WOS:000664333800013)】；

基金：This work was supported by the National Natural Science Foundation of China (21801077, 22071056), The Shanghai Sailing Program (18YF1406200), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：asymmetric catalysis; Conia-ene reaction; chiral spirocycle; disilver/bisdiamine complex; DFT calculations

摘要：Chiral all-carbon spirocycles emerge in a wide variety of natural products exhibiting biological and pharmacological activities. We present the disilver(I)/bisdiamine complex catalyzed asymmetric vinylogous Conia-ene reaction of gamma'-pentynecyclohex-3-enones for the direct synthesis of chiral all-carbon spirocycles. The synergistic catalysis of silver(I) and the amine provided the vinylogous adducts in good yields with high enantioselectivities. DFT calculations verified the regioselectivity and enantioselectivity of the reaction and highlighted the high catalytic activity of the disilver(I)/bisdiamine complex. In addition, various polycyclic products were achieved by derivatization of the spirocyclic enones.