文献类型：期刊文献

英文题名：Simultaneous incorporation of gallium oxide and tantalum microparticles into micro-arc oxidation coating of titanium possessing antibacterial effect and stimulating cellular response

作者：Wang, Fan[1];Wang, Xuehong[1];Xie, En[1];Gan, Qi[1];Ping, Sun[2];Wei, Jie[1];Li, Fengqian[2];Wang, Zimin[3]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]Shanghai Eighth Peoples Hosp, Dept Orthopaed, Shanghai 200235, Peoples R China;[3]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthopaed Surg, Sch Med, Shanghai 200011, Peoples R China

年份：2022

卷号：135

外文期刊名：BIOMATERIALS ADVANCES

收录：;EI(收录号：20222512262513);WOS:【SCI-EXPANDED(收录号:WOS:000812233100007)】；

基金：The grants were from the National Natural Science Foundation of China (32171340, 81572211, 32071337 and 81972060) and Natural Science Foundation of Shanghai (21ZR1447900) and Shanghai Pujiang Program (20PJ1402600) .

语种：英文

外文关键词：Titanium micro-arc oxidation; Tantalum; Gallium oxide; Osteogenic properties; Antibacterial functions

摘要：Orthopedic implants with both osteogenesis and antibacterial functions are particularly promising for bone repair and substitutes. In this study, a micro-arc oxidation (MAO) coating containing titanium dioxide (TiO2), gallium oxide (Ga2O3) and tantalum oxide (Ta2O5) on the titanium surface (MGT) was fabricated by dispersing Ga2O3 and Ta microparticles in the electrolyte. The results showed that the simultaneous incorporation of Ga(2)O(3 )and Ta microparticles into the MAO coating resulted in optimized surface performance (e.g., micro-topography, roughness, wettability, surface energy, and protein absorption) of MGT compared with pure titanium (pTi). In addition, MGT exhibited outstanding corrosion resistance owing to the presence of both Ga2O3 and Ta microparticles, which exhibit excellent corrosion resistance and their microparticles were incorporated into the micropores of the coating. Moreover, MGT with good cytocompatibility and optimized surface resulted in improved cellular responses (e.g., proliferation and osteogenic differentiation) of rat bone mesenchymal stem cells, which was attributed to Ta microparticles with outstanding osteogenic bioactivity. Furthermore, the excellent antibacterial effect of MGT was attributed to the slow release of Ga3+ from the coating. Thus, the simultaneous incorporation of Ga2O3 and Ta microparticles into the MAO coating of MGT exhibited excellent cytocompatibility, osteogenic bioactivity, antibacterial functions, and corrosion resistance, suggesting that MGT possesses great potential for bone repair applications.