文献类型：期刊文献

英文题名：Stereoselective α-indolylation of enals via an organocatalytic formal cross-coupling with indoles

作者：Hu, Yang[1];Ju, Lei[1];Lu, Lin[1];Ma, Hongmei[1];Yu, Xinhong[1]

机构：[1]E China Univ Sci & Technol, Shanghai 200237, Peoples R China

年份：2015

卷号：13

期号：33

起止页码：8869

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20153301170529);WOS:【SCI-EXPANDED(收录号:WOS:000359458700011)，CCR-EXPANDED(收录号:WOS:000359458700011)】；

基金：We gratefully acknowledge financial support from the National Science Foundation of China (20972051 and 21476078) and the Science and Technology Commission of Shanghai Municipality (12431900900, 12431900902, 08431901800 and 08430703900). We thank Professor Dr Wei Wang for helpful discussion.

语种：英文

摘要：We report a novel organocatalytic one-pot cascade bromination-Michael-type Friedel-Crafts alkylation dearomatization-nucleophilic rearrangement aromatization cascade process for the direct alpha-indolylation of unfunctionalized enals from readily available indoles with good yields and high E selectivity. The simplicity and practicality of its high efficiency for formation of a new C(sp(2))-C(sp(2)) bond constitute the most attractive advantage of this reaction.