文献类型：期刊文献

英文题名：Extraction-Induced Fabrication of Yolk-Shell-Structured Nanoparticles with Deformable Micellar Cores and Mesoporous Silica Shells for Multidrug Delivery

作者：Niu, Dechao[1];Jiang, Yu[1];He, Jianping[1];Jia, Xiaobo[1];Qin, Limei[1];Hao, Jina[1];Zhao, Wenru[1];Dai, Bin[2];Li, Yongsheng[1]

机构：[1]East China Univ Sci & Technol, Shanghai Engn Res Ctr Hierarch Nanomat, Key Lab Ultrafine Mat Minist Educ,Sch Mat Sci & E, Lab Low Dimens Mat Chem, Shanghai 200237, Peoples R China;[2]Shihezi Univ, Sch Chem & Chem Engn, Shihezi 832000, Xinjiang, Peoples R China

年份：2019

卷号：2

期号：12

起止页码：5707

外文期刊名：ACS APPLIED BIO MATERIALS

收录：EI(收录号：20194707710549);WOS:【ESCI(收录号:WOS:000616372300041)】；

基金：This work was financially supported by the National Key Research and Development Program of China (2018YFC1105702 and 2016YFA0203700), The National Natural Science Foundation of China for Innovative Research Groups (51621002), NSFC (51572083, 51572084, and 51972112), Program of Shanghai Academic/Technology Research Leader (18XD1401400), Research Program of Shanghai (17JC1404702), Leading talents in Shanghai in 2018, The Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, and The 111 project (B14018), and the Fundamental Research Funds for Central Universities (222201718002).

语种：英文

外文关键词：yolk-shell structure; block copolymer; mesoporous silica; multidrug delivery; tumor chemotherapy

摘要：Yolk-shell-structured nanoparticles (YSNs) provide useful carriers for applications in biomedicine and catalysis due to the excellent loading capability and versatile functionality of the flexible core and porous shell. Unfortunately, the reported YSNs always require complex multistep synthesis processes and a harsh hard-template etching strategy. Herein, a facile "selective extraction" strategy is developed to synthesize yolk-shell-structured polymer@void@mSiO(2) nanoparticles (designated as YSPNs) comprising deformable and soft polystyrene-b-poly(acrylic acid) (PSb-PAA) micellar cores and mesoporous silica shells. The YSPNs are formed by a morphological change and volume shrinkage of the PS-b-PAA aggregates from large compound vesicles to large compound micelles during the extraction process. As a multidrug vehicle, both hydrophobic curcumin (Cur, 6.4 wt %) and hydrophilic doxorubicin hydrochloride (Dox, 19.4 wt %) can be coloaded onto YSPNs through a successive impregnation method. Moreover, the resulting Cur/Dox@YSPNs possess intelligent pH-responsive capability, time-sequenced release behavior, and high in vivo antitumor efficiency, demonstrating excellent potential as safe and efficient multidrug nanocarriers for tumor chemotherapy. We envision that such a facile "selective extraction" strategy will enable pathways to construct organic-inorganic hybrid nanoparticles with yolk-shell structures for various applications.