文献类型：期刊文献

英文题名：A modified microfluidic chip for fabrication of paclitaxel-loaded poly(l-lactic acid) microspheres

作者：He, Tianxi[1,2];Liang, Qionglin[1];Zhang, Kai[3];Mu, Xuan[3];Luo, Tingting[3];Wang, Yiming[1];Luo, Guoan[1]

机构：[1]Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China;[2]Logist Engn Univ, Chongqing 400016, Peoples R China;[3]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2011

卷号：10

期号：6

起止页码：1289

外文期刊名：MICROFLUIDICS AND NANOFLUIDICS

收录：;EI(收录号：20112113997570);WOS:【SCI-EXPANDED(收录号:WOS:000290581900013)】；

基金：This research was supported by funding from National Basic Research Program (973 Program) of China (No. 2007CB714505), National Major Special Project of Science and Technology (No. 2009ZX09311-01) and Ministry of Education of China (No. 20080031012). The authors would like to thank Professor Zhang Xi (Tsinghua University) for measuring contact angle, ATR-FTIR and AFM images.

语种：英文

外文关键词：Microfluidic; Droplets; Poly(L-lactic acid) microsphere; Paclitaxel; Drug delivery; Monodisperse

摘要：In this article, we present a simple PDMS surface modification method based on poly(vinyl alcohol)/glycerol (PVA/Gly) solution immersion, self-assembled absorption, and heat treatment. The results of contact angle and ATR-FTIR demonstrate the superhydrophilic surface in modified PDMS. It can allow for the stable production of monodisperse droplet in a highly reproducible manner. In addition, we demonstrate the fabrication of monodisperse paclitaxel (PTX) loaded poly(l-lactic acid) (PLLA) microspheres on this kind of modification chip with solvent evaporation. The PLLA microspheres can be adjusted to a range of different sizes depending on the system flow rate. Determination of microsphere size is carried out by optical microscopy and image analysis to reveal less than 4% variation in microsphere size. Compared with the results of published papers, the presented data demonstrate that PTX-loaded PLLA microspheres show good physical properties (spherical and discrete), high-drug loading, encapsulation efficiency, a small initial burst, and sustained-release behavior due to outstanding monodispersity. With the characteristic to prepare high-quality, monodisperse, biodegradable microspheres, the versatile and simple microfluidic method facilitates the development of more reliable and reproducible drug delivery systems, which have great potential to benefit pharmaceutical and biological applications.